Mechanistic Target of Rapamycin Complex 1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

Also Known As:

TOR Complex 1; TORC1; Target of Rapamycin Complex 1; mTORC1; mTORC1 Complex; Complex, mTORC1

Macromolecular Substances: 97
- Multiprotein Complexes: 128
  - Mechanistic Target of Rapamycin Complex 1: 3831
Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein Serine-Threonine Kinases: 3707
        TOR Serine-Threonine Kinases: 6109
        Mechanistic Target of Rapamycin Complex 1: 3831
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3707
      - TOR Serine-Threonine Kinases: 6109
        Mechanistic Target of Rapamycin Complex 1: 3831

Audrey Raibon Selected Research

Audrey Raibon Research Topics

Disease

Drug/Important Bio-Agent (IBA)